Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

Molecular recognition plays a central role in biology, and protein dynamics has been acknowledged to be important in this process. However, it is highly debated whether conformational changes happen before ligand binding to produce a binding-competent state (conformational selection) or are caused i...

Full description

Bibliographic Details
Main Authors: Kalyan S. Chakrabarti, Roman V. Agafonov, Francesco Pontiggia, Renee Otten, Matthew K. Higgins, Gebhard F.X. Schertler, Daniel D. Oprian, Dorothee Kern
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
conformational ensemble
conformational selection
energy landscape
molecular recognition dynamics
protein/protein interaction
recoverin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014230

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715014230

Similar Items