A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)

Abstract Background Tolerogenic vaccines represent antigen-specific interventions designed to re-establish self-tolerance and thereby alleviate autoimmune diseases, which collectively comprise over 100 chronic inflammatory diseases afflicting more than 20 million Americans. Tolerogenic vaccines comp...

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Bibliographic Details
Main Authors: Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca, Mark D. Mannie
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
FOXP3+ Tregs
Immune tolerance
Tolerogenic vaccine
EAE/MS
Neuroimmunology
GM-CSF
Online Access:http://link.springer.com/article/10.1186/s12974-020-01856-8

Internet

http://link.springer.com/article/10.1186/s12974-020-01856-8

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