Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI). Like most other complex traits, LDD is likely polygenic and influenced by both...

Full description

Bibliographic Details
Main Authors: Xueya Zhou, Ching-Lung Cheung, Tatsuki Karasugi, Jaro Karppinen, Dino Samartzis, Yi-Hsiang Hsu, Timothy Shin-Heng Mak, You-Qiang Song, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yan Li, Danny Chan, Kenneth Man-Chee Cheung, Shiro Ikegawa, Kathryn Song-Eng Cheah, Pak Chung Sham
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Genetics
Subjects:
polygenic score
genetic correlation
causality
pleiotropy
lumbar disc degeneration
osteoarthritis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00267/full

Similar Items

Similar Items