Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidat...

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Bibliographic Details
Main Authors: Arianna Luise, Elena De Cecco, Erika Ponzini, Martina Sollazzo, PierLuigi Mauri, Frank Sobott, Giuseppe Legname, Rita Grandori, Carlo Santambrogio
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
methionine sulfoxide
human β-synuclein
dopamine oxidation
proteoforms relative quantitation
top-down mass spectrometry
Online Access:https://www.mdpi.com/2076-3921/10/6/893

Internet

https://www.mdpi.com/2076-3921/10/6/893

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