MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown that constitutive activation of the JAK-STAT signal transduction pathway is an important pathogeneti...

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Bibliographic Details
Main Authors: Yana Pikman, Benjamin H Lee, Thomas Mercher, Elizabeth McDowell, Benjamin L Ebert, Maricel Gozo, Adam Cuker, Gerlinde Wernig, Sandra Moore, Ilene Galinsky, Daniel J DeAngelo, Jennifer J Clark, Stephanie J Lee, Todd R Golub, Martha Wadleigh, D Gary Gilliland, Ross L Levine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-07-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1502153?pdf=render

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http://europepmc.org/articles/PMC1502153?pdf=render

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