Ribotype Classification of Clostridioides difficile Isolates Is Not Predictive of the Amino Acid Sequence Diversity of the Toxin Virulence Factors TcdA and TcdB

Ribotype Classification of Clostridioides difficile Isolates Is Not Predictive of the Amino Acid Sequence Diversity of the Toxin Virulence Factors TcdA and TcdB

Clostridioides (Clostridium) difficile is the most commonly recognized cause of infectious diarrhea in healthcare settings. Currently there is no vaccine to prevent initial or recurrent C. difficile infection (CDI). Two large clostridial toxins, TcdA and TcdB, are the primary virulence factors for C...

Full description

Bibliographic Details
Main Authors: Zhenghui Li, Kwok Lee, Urvi Rajyaguru, C. Hal Jones, Sandra Janezic, Maja Rupnik, Annaliesa S. Anderson, Paul Liberator
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
Clostridioides difficile
Clostridium difficile
TcdA
TCDB
vaccines
whole genome sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01310/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01310/full

Similar Items