TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells.

TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells.

Accumulation of ubiquitin-positive, tau- and α-synuclein-negative intracellular inclusions of TDP-43 in the central nervous system represents the major hallmark correlated to amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions. Such inclusions have...

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Bibliographic Details
Main Authors: Claudia Capitini, Simona Conti, Michele Perni, Francesca Guidi, Roberta Cascella, Angela De Poli, Amanda Penco, Annalisa Relini, Cristina Cecchi, Fabrizio Chiti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3907574?pdf=render

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http://europepmc.org/articles/PMC3907574?pdf=render

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