The N-terminal helix controls the transition between the soluble and amyloid states of an FF domain.

by Virginia Castillo, Fabrizio Chiti, Salvador Ventura
Published 2013-01-01

Aggregation propensity of the human proteome.

by Elodie Monsellier, Matteo Ramazzotti, Niccolò Taddei, Fabrizio Chiti
Published 2008-10-01

A computational approach for identifying the chemical factors involved in the glycosaminoglycans-mediated acceleration of amyloid fibril formation.

by Elodie Monsellier, Matteo Ramazzotti, Niccolò Taddei, Fabrizio Chiti
Published 2010-06-01

Insight into the structure of amyloid fibrils from the analysis of globular proteins.

by Antonio Trovato, Fabrizio Chiti, Amos Maritan, Flavio Seno
Published 2006-12-01

Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43

by Mirella Vivoli-Vega, Prandvera Guri, Fabrizio Chiti, Francesco Bemporad
Published 2020-08-01

Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases

by Roberta Cascella, Giulia Fani, Alessandra Bigi, Fabrizio Chiti, Cristina Cecchi
Published 2019-07-01

Soluble Prion Peptide 107–120 Protects Neuroblastoma SH-SY5Y Cells against Oligomers Associated with Alzheimer’s Disease

by Elham Rezvani Boroujeni, Seyed Masoud Hosseini, Giulia Fani, Cristina Cecchi, Fabrizio Chiti
Published 2020-10-01

Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation

by Hassan Ramshini, Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi, Fabrizio Chiti
Published 2019-11-01

Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans

by Michele Perni, Benedetta Mannini, Catherine K. Xu, Janet R. Kumita, Christopher M. Dobson, Fabrizio Chiti, Michele Vendruscolo
Published 2021-07-01

Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils.

by Hassan Ramshini, Claudia Parrini, Annalisa Relini, Mariagioia Zampagni, Benedetta Mannini, Alessandra Pesce, Ali Akbar Saboury, Mohsen Nemat-Gorgani, Fabrizio Chiti
Published 2011-01-01

TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells.

by Claudia Capitini, Simona Conti, Michele Perni, Francesca Guidi, Roberta Cascella, Angela De Poli, Amanda Penco, Annalisa Relini, Cristina Cecchi, Fabrizio Chiti
Published 2014-01-01

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

by Roberta Cascella, Serene W. Chen, Alessandra Bigi, José D. Camino, Catherine K. Xu, Christopher M. Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi
Published 2021-03-01

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.

by Leila M Luheshi, Gian Gaetano Tartaglia, Ann-Christin Brorsson, Amol P Pawar, Ian E Watson, Fabrizio Chiti, Michele Vendruscolo, David A Lomas, Christopher M Dobson, Damian C Crowther
Published 2007-10-01

Homage to Chris Dobson

by Jean Baum, Fabrizio Chiti, Alfonso De Simone, Tuomas P. J. Knowles, Janet R. Kumita, Sheena E. Radford, Carol V. Robinson, Xavier Salvatella, Karen Valelli, Michele Vendruscolo, Annalisa Pastore, Gian Gaetano Tartaglia
Published 2019-12-01

Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

by Ryan Limbocker, Benedetta Mannini, Rodrigo Cataldi, Shianne Chhangur, Aidan K. Wright, Ryan P. Kreiser, J. Alex Albright, Sean Chia, Johnny Habchi, Pietro Sormanni, Janet R. Kumita, Francesco S. Ruggeri, Christopher M. Dobson, Fabrizio Chiti, Francesco A. Aprile, Michele Vendruscolo
Published 2020-06-01

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

by Ryan Limbocker, Sean Chia, Francesco S. Ruggeri, Michele Perni, Roberta Cascella, Gabriella T. Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C. T. Michaels, Pavan K. Challa, Minkoo Ahn, Samuel T. Casford, Nilumi Fernando, Catherine K. Xu, Nina D. Kloss, Samuel I. A. Cohen, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P. J. Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M. Dobson
Published 2019-01-01

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

by Ryan Limbocker, Ryan Limbocker, Roxine Staats, Sean Chia, Francesco S. Ruggeri, Francesco S. Ruggeri, Francesco S. Ruggeri, Benedetta Mannini, Catherine K. Xu, Michele Perni, Roberta Cascella, Alessandra Bigi, Liam R. Sasser, Natalie R. Block, Aidan K. Wright, Ryan P. Kreiser, Edward T. Custy, Georg Meisl, Silvia Errico, Silvia Errico, Johnny Habchi, Patrick Flagmeier, Tadas Kartanas, Jared E. Hollows, Lam T. Nguyen, Kathleen LeForte, Denise Barbut, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Michael Zasloff, Tuomas P. J. Knowles, Tuomas P. J. Knowles, Christopher M. Dobson, Fabrizio Chiti, Michele Vendruscolo
Published 2021-06-01