Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

by Ryan Limbocker, Ryan Limbocker, Roxine Staats, Sean Chia, Francesco S. Ruggeri, Francesco S. Ruggeri, Francesco S. Ruggeri, Benedetta Mannini, Catherine K. Xu, Michele Perni, Roberta Cascella, Alessandra Bigi, Liam R. Sasser, Natalie R. Block, Aidan K. Wright, Ryan P. Kreiser, Edward T. Custy, Georg Meisl, Silvia Errico, Silvia Errico, Johnny Habchi, Patrick Flagmeier, Tadas Kartanas, Jared E. Hollows, Lam T. Nguyen, Kathleen LeForte, Denise Barbut, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Michael Zasloff, Tuomas P. J. Knowles, Tuomas P. J. Knowles, Christopher M. Dobson, Fabrizio Chiti, Michele Vendruscolo
Published 2021-06-01

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

by Ryan Limbocker, Sean Chia, Francesco S. Ruggeri, Michele Perni, Roberta Cascella, Gabriella T. Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C. T. Michaels, Pavan K. Challa, Minkoo Ahn, Samuel T. Casford, Nilumi Fernando, Catherine K. Xu, Nina D. Kloss, Samuel I. A. Cohen, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P. J. Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M. Dobson
Published 2019-01-01

Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

by Robert A. Hauser, Dean Sutherland, Juan A. Madrid, Maria Angeles Rol, Steven Frucht, Stuart Isaacson, Fernando Pagan, Brian N. Maddux, George Li, Winona Tse, Benjamin L. Walter, Rajeev Kumar, Daniel Kremens, Mark F. Lew, Aaron Ellenbogen, Odinachi Oguh, Alberto Vasquez, William Kinney, Matt Lowery, Maria Resnick, Nicole Huff, Jerry Posner, Karla V. Ballman, Brian E. Harvey, Michael Camilleri, Michael Zasloff, Denise Barbut
Published 2019-01-01

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

by Michele Perni, Annemieke van der Goot, Ryan Limbocker, Ryan Limbocker, Tjakko J. van Ham, Francesco A. Aprile, Catherine K. Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco, Serene W. Chen, Pavan K. Challa, Julius B. Kirkegaard, Romain F. Laine, Kai Yu Ma, Kai Yu Ma, Martin B. D. Müller, Martin B. D. Müller, Tessa Sinnige, Janet R. Kumita, Samuel I. A. Cohen, Renée Seinstra, Gabriele S. Kaminski Schierle, Clemens F. Kaminski, Denise Barbut, Alfonso De Simone, Tuomas P. J. Knowles, Michael Zasloff, Ellen A. A. Nollen, Michele Vendruscolo, Christopher M. Dobson
Published 2021-03-01