Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors

Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission can be an effective therapeutic strategy toward AD. Herein, we report for...

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Bibliographic Details
Main Authors: Catarina Oliveira, Fernando Cagide, José Teixeira, Ricardo Amorim, Lisa Sequeira, Francesco Mesiti, Tiago Silva, Jorge Garrido, Fernando Remião, Santiago Vilar, Eugenio Uriarte, Paulo J. Oliveira, Fernanda Borges
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Chemistry
Subjects:
hydroxybenzoic acids
oxidative stress
mitochondria-targeted antioxidants
cholinesterase inhibitors
acetyl and butyrylcholinesterase
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00126/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00126/full

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