In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from <i>Corydalis cava</i> (Papaveraceae). Inhibitory activities of (+)-thalictricavine (<b>1</b>) and (+)-canadine (<b>2</b>) on human acetylcholinesterase (<i>h</i>...

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Bibliographic Details
Main Authors: Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I. Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera, Martina Hrabinová, Daniel Jun
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
(+)-thalictricavine
(+)-canadine
cholinesterases
kinetic study
molecular docking
blood–brain barrier permeability
Online Access:https://www.mdpi.com/1420-3049/24/7/1340

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https://www.mdpi.com/1420-3049/24/7/1340

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