Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice

by Jiří Kassa, Jan Korábečný
Published 2018-04-01

Cholinesterase Research

by Jan Korabecny, Ondrej Soukup
Published 2021-07-01

Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer

by Lukas Gorecki, Martin Andrs, Jan Korabecny
Published 2021-02-01

The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice

by Jiří Kassa, Jan Korábečný, Eugenie Nepovimová
Published 2017-06-01

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing th...

by Jan Misik, Jan Korabecny, Eugenie Nepovimova, Pavla Cabelova, Jiri Kassa
Published 2015-12-01

Preparation of the Pyridinium Salts Differing in the Length of the N-Alkyl Substituent

by Kamil Musilek, Jan Korabecny, Miroslav Pohanka, Ondrej Soukup, Jiri Cabal, Petr Stodulka, Jan Marek, Kamil Kuca
Published 2010-03-01

Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

by Kamil Kuca, Brian J. Bennion, Rafael Dolezal, Filip Zemek, Vendula Sepsova, Jana Zdarova Karasova, Jan Korabecny
Published 2013-08-01

7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies

by Kamil Kuca, Katarina Siposova, Lucie Drtinova, Zuzana Gazova, Ondrej Soukup, Kamil Musilek, Anna Horova, Katarina Spilovska, Jan Korabecny, Jan Kral
Published 2013-02-01

Profiling donepezil template into multipotent hybrids with antioxidant properties

by Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny
Published 2018-01-01

Amaryllidaceae Alkaloids of Belladine-Type from <i>Narcissus pseudonarcissus</i> cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase

by Abdullah Al Mamun, Jana Maříková, Daniela Hulcová, Jiří Janoušek, Marcela Šafratová, Lucie Nováková, Tomáš Kučera, Martina Hrabinová, Jiří Kuneš, Jan Korábečný, Lucie Cahlíková
Published 2020-05-01

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

by Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny
Published 2019-08-01

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

by Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I. Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera, Martina Hrabinová, Daniel Jun
Published 2019-04-01

Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer's Disease Treatment

by Jiri Patocka, Jan Korabecny, Kamil Kuca, Zdenek Fisar, Jana Hroudova, Florian Nachon, Vlastimil Dohnal, Filip Zemek, Veronika Opletalova, Daniel Jun, Eugenie Nepovimova, Ondrej Holas, Kamil Musilek
Published 2010-12-01

Investigation of New Orexin 2 Receptor Modulators Using <i>In Silico</i> and In Vitro Methods

by Jana Janockova, Rafael Dolezal, Eugenie Nepovimova, Tereza Kobrlova, Marketa Benkova, Kamil Kuca, Jan Konecny, Eva Mezeiova, Michaela Melikova, Vendula Hepnarova, Avi Ring, Ondrej Soukup, Jan Korabecny
Published 2018-11-01

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

by David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek
Published 2020-01-01

Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids

by Jana Maříková, Abdullah Al Mamun, Latifah Al Shammari, Jan Korábečný, Tomáš Kučera, Daniela Hulcová, Jiří Kuneš, Milan Malaník, Michaela Vašková, Eliška Kohelová, Lucie Nováková, Lucie Cahlíková, Milan Pour
Published 2021-02-01

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

by Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Anna Horova, David Malinak, Eva Mezeiova, Lukas Gorecki, Vendula Sepsova, Martina Hrabinova, Ondrej Soukup, Daniel Jun, Kamil Kuca
Published 2015-12-01

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease

by Eliška Kohelová, Rozálie Peřinová, Negar Maafi, Jan Korábečný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Loreto Martínez González, Martina Hrabinova, Katarina Vorčáková, Lucie Nováková, Angela De Simone, Radim Havelek, Lucie Cahlíková
Published 2019-04-01

Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D₂ 3,4-dihydroquinolin-2(1<i>H</i>)-one Derivatives Related to Aripiprazole

by Radomir Juza, Kristyna Stefkova, Wim Dehaen, Alena Randakova, Tomas Petrasek, Iveta Vojtechova, Tereza Kobrlova, Lenka Pulkrabkova, Lubica Muckova, Marko Mecava, Lukas Prchal, Eva Mezeiova, Kamil Musilek, Ondrej Soukup, Jan Korabecny
Published 2021-08-01

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and <i>N</i>-Methyl-d-Aspartate Receptor Antagonists

by Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva, Stepan Kortus, Daniel Jun, Marian Valko, Martin Horak, Ondrej Soukup, Jan Korabecny
Published 2021-12-01