Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells.

Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells.

We previously reported that TR2 and TR4 orphan nuclear receptors bind to direct repeat (DR) elements in the ε- and γ-globin promoters, and act as molecular anchors for the recruitment of epigenetic corepressors of the multifaceted DRED complex, thereby leading to ε- and γ-globin transcriptional repr...

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Bibliographic Details
Main Authors: Lihong Shi, M C Sierant, Katherine Gurdziel, Fan Zhu, Shuaiying Cui, Katarzyna E Kolodziej, John Strouboulis, Yuanfang Guan, Osamu Tanabe, Kim-Chew Lim, James Douglas Engel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4014424?pdf=render

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http://europepmc.org/articles/PMC4014424?pdf=render

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