Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a major neuropathological hallmark of Parkinson's disease (PD). At present, the generation of large nuclear-associated Lewy bodies from endogenous wild-type α-synucle...

Full description

Bibliographic Details
Main Authors: Teresa R. Taylor-Whiteley, Christine L. Le Maitre, James A. Duce, Caroline F. Dalton, David P. Smith
Format: Article
Language:English
Published: The Company of Biologists 2019-04-01
Series:Disease Models & Mechanisms
Subjects:
3D cell culture
Amyloid
Lewy body
Oligomer
Parkinson's
Synuclein
Online Access:http://dmm.biologists.org/content/12/4/dmm038042

Internet

http://dmm.biologists.org/content/12/4/dmm038042

Similar Items