PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages

PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages

It was previously shown that secretion of PE-PGRS and PPE-MPTR proteins is abolished in clinical M. tuberculosis isolates with a deletion in the ppe38-71 operon, which is associated with increased virulence. Here we investigate the proteins dependent on PPE38 for their secretion and their role in th...

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Bibliographic Details
Main Authors: James Gallant, Tiaan Heunis, Caroline Beltran, Karin Schildermans, Sven Bruijns, Inge Mertens, Wilbert Bitter, Samantha L. Sampson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
proteomics
NF-KB signalling
PE/PPE
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702359/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.702359/full

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