Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control

The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological oxidative stress and/or disrupted protein degradatio...

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Bibliographic Details
Main Authors: Daniela Strobbe, Alexis A. Robinson, Kirsten Harvey, Lara Rossi, Caterina Ferraina, Valerio de Biase, Carlo Rodolfo, Robert J. Harvey, Michelangelo Campanella
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mitochondria
mitophagy
DJ-1
DJBP/EFCAB6
PARK7
SUMO-1
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00068/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00068/full

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