PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related neurodegeneration. Although the cellular functions of LRRK2 in health and disease are incompletely understood, robust e...

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Bibliographic Details
Main Authors: Laura Civiero, Susanna Cogo, Anneleen Kiekens, Claudia Morganti, Isabella Tessari, Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Cinzia Franchin, Giorgio Arrigoni, Patrick A. Lewis, Giovanni Piccoli, Luigi Bubacco, Mark R. Cookson, Paolo Pinton, Elisa Greggio
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
PAK6
14-3-3
LRRK2
Parkinson's disease
phosphorylation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00417/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00417/full

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