Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids

Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids

A library of seventeen novel ether phospholipid analogues, containing 5-membered heterocyclic rings (1,2,3-triazolyl, isoxazolyl, 1,3,4-oxadiazolyl and 1,2,4-oxadiazolyl) in the lipid portion were designed and synthesized aiming to identify optimised miltefosine analogues. The compounds were evaluat...

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Bibliographic Details
Main Authors: George E. Magoulas, Pantelis Afroudakis, Kalliopi Georgikopoulou, Marina Roussaki, Chiara Borsari, Theano Fotopoulou, Nuno Santarem, Emile Barrias, Paloma Tejera Nevado, Julia Hachenberg, Eugenia Bifeld, Bernhard Ellinger, Maria Kuzikov, Irini Fragiadaki, Effie Scoulica, Joachim Clos, Sheraz Gul, Maria Paola Costi, Wanderley de Souza, Kyriakos C. Prousis, Anabela Cordeiro da Silva, Theodora Calogeropoulou
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
ether phospholipids
heterocyclic rings
antiparasitic activity
<i>Leishmania</i> <i>infantum</i>
<i>Leishmania donovani</i>
<i>Trypanosoma brucei</i>
Online Access:https://www.mdpi.com/1420-3049/26/14/4204

Internet

https://www.mdpi.com/1420-3049/26/14/4204

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