Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation

Summary: The RNA N6-methyladenosine (m6A) methylation is installed by the METTL3-METTL14 methyltransferase complex. This modification has critical regulatory roles in various biological processes. Here, we report that deletion of Mettl14 dramatically reduces mRNA m6A methylation in developing B cell...

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Bibliographic Details
Main Authors:	Zhong Zheng, Linda Zhang, Xiao-Long Cui, Xianbin Yu, Phillip J. Hsu, Ruitu Lyu, Haiyan Tan, Malay Mandal, Michelle Zhang, Hui-Lung Sun, Arantxa Sanchez Castillo, Junmin Peng, Marcus R. Clark, Chuan He, Haochu Huang
Format:	Article
Language:	English
Published:	Elsevier 2020-06-01
Series:	Cell Reports
Subjects:	B cell development RNA m6A modification METTL14 YTHDF2 Post-transcriptional regulation of gene expression
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124720308007

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http://www.sciencedirect.com/science/article/pii/S2211124720308007

Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation

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