Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

The family of DNA methyltransferases (Dnmts) consists of four catalytically active enzymes that catalyze DNA methylation and also play a role as transcriptional regulators. Here the authors show that catalytically inactive Dnmt3b rescues a majority of methylation and expression changes in the absenc...

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Bibliographic Details
Main Authors: Pawel Nowialis, Katarina Lopusna, Jana Opavska, Staci L. Haney, Ajay Abraham, Peike Sheng, Alberto Riva, Amarnath Natarajan, Olga Guryanova, Melanie Simpson, Ryan Hlady, Mingyi Xie, Rene Opavsky
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12355-7

Internet

https://doi.org/10.1038/s41467-019-12355-7

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