Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells

Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells

Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased versus normal human cohorts as they emerge during in vitr...

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Bibliographic Details
Main Authors: Andrew A. Wilson, Lei Ying, Marc Liesa, Charis-Patricia Segeritz, Jason A. Mills, Steven S. Shen, Jyhchang Jean, Geordie C. Lonza, Derek C. Liberti, Alex H. Lang, Jean Nazaire, Adam C. Gower, Franz-Josef Müeller, Pankaj Mehta, Adriana Ordóñez, David A. Lomas, Ludovic Vallier, George J. Murphy, Gustavo Mostoslavsky, Avrum Spira, Orian S. Shirihai, Maria I. Ramirez, Paul Gadue, Darrell N. Kotton
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000776

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http://www.sciencedirect.com/science/article/pii/S2213671115000776

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