A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

Telomeric G-quadruplexes (G4) were long believed to form a protective structure at telomeres, preventing their extension by the ribonucleoprotein telomerase. Contrary to this belief, we have previously demonstrated that parallel-stranded conformations of telomeric G4 can be extended by human and cil...

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Bibliographic Details
Main Authors: Bishnu P Paudel, Aaron Lavel Moye, Hala Abou Assi, Roberto El-Khoury, Scott B Cohen, Jessica K Holien, Monica L Birrento, Siritron Samosorn, Kamthorn Intharapichai, Christopher G Tomlinson, Marie-Paule Teulade-Fichou, Carlos González, Jennifer L Beck, Masad J Damha, Antoine M van Oijen, Tracy M Bryan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
telomerase
G-quadruplex
telomere
Online Access:https://elifesciences.org/articles/56428

Internet

https://elifesciences.org/articles/56428

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