Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells

Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells

Adoptive T cell therapies for solid tumors is challenging. We generated metabolically enhanced co-activated-T cells by transducing intracellular co-stimulatory (41BB, ICOS or ICOS-27) and CD3ζ T cell receptor signaling domains followed by arming with bispecific antibodies (BiAbs) to produce armed “H...

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Bibliographic Details
Main Authors: Archana Thakur, John Scholler, Ewa Kubicka, Edwin T. Bliemeister, Dana L. Schalk, Carl H. June, Lawrence G. Lum
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
breast cancer
pancreatic cancer
activated T cells
co-activated T cells
bispecific antibody
headless CAR T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.690437/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.690437/full

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