miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma.

miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma.

In contrast to normal differentiated cells that depend on mitochondrial oxidative phosphorylation for energy production, cancer cells have evolved to utilize aerobic glycolysis (Warburg's effect), with benefit of providing intermediates for biomass production. MicroRNA-122 (miR-122) is highly e...

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Bibliographic Details
Main Authors: Angela M Liu, Zhi Xu, Felix H Shek, Kwong-Fai Wong, Nikki P Lee, Ronnie T Poon, Jinfei Chen, John M Luk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900676?pdf=render

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http://europepmc.org/articles/PMC3900676?pdf=render

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