A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepat...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25468-9 |
| id |
doaj-454d7d31ae1e40b7812cd73b90a2e7e3 |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Emilie Crouchet Simonetta Bandiera Naoto Fujiwara Shen Li Hussein El Saghire Mirian Fernández-Vaquero Tobias Riedl Xiaochen Sun Hadassa Hirschfield Frank Jühling Shijia Zhu Natascha Roehlen Clara Ponsolles Laura Heydmann Antonio Saviano Tongqi Qian Anu Venkatesh Joachim Lupberger Eloi R. Verrier Mozhdeh Sojoodi Marine A. Oudot François H. T. Duong Ricard Masia Lan Wei Christine Thumann Sarah C. Durand Victor González-Motos Danijela Heide Jenny Hetzer Shigeki Nakagawa Atsushi Ono Won-Min Song Takaaki Higashi Roberto Sanchez Rosa S. Kim C. Billie Bian Karun Kiani Tom Croonenborghs Aravind Subramanian Raymond T. Chung Beate K. Straub Detlef Schuppan Maliki Ankavay Laurence Cocquerel Evelyne Schaeffer Nicolas Goossens Anna P. Koh Milind Mahajan Venugopalan D. Nair Ganesh Gunasekaran Myron E. Schwartz Nabeel Bardeesy Alex K. Shalek Orit Rozenblatt-Rosen Aviv Regev Emanuele Felli Patrick Pessaux Kenneth K. Tanabe Mathias Heikenwälder Catherine Schuster Nathalie Pochet Mirjam B. Zeisel Bryan C. Fuchs Yujin Hoshida Thomas F. Baumert |
| spellingShingle |
Emilie Crouchet Simonetta Bandiera Naoto Fujiwara Shen Li Hussein El Saghire Mirian Fernández-Vaquero Tobias Riedl Xiaochen Sun Hadassa Hirschfield Frank Jühling Shijia Zhu Natascha Roehlen Clara Ponsolles Laura Heydmann Antonio Saviano Tongqi Qian Anu Venkatesh Joachim Lupberger Eloi R. Verrier Mozhdeh Sojoodi Marine A. Oudot François H. T. Duong Ricard Masia Lan Wei Christine Thumann Sarah C. Durand Victor González-Motos Danijela Heide Jenny Hetzer Shigeki Nakagawa Atsushi Ono Won-Min Song Takaaki Higashi Roberto Sanchez Rosa S. Kim C. Billie Bian Karun Kiani Tom Croonenborghs Aravind Subramanian Raymond T. Chung Beate K. Straub Detlef Schuppan Maliki Ankavay Laurence Cocquerel Evelyne Schaeffer Nicolas Goossens Anna P. Koh Milind Mahajan Venugopalan D. Nair Ganesh Gunasekaran Myron E. Schwartz Nabeel Bardeesy Alex K. Shalek Orit Rozenblatt-Rosen Aviv Regev Emanuele Felli Patrick Pessaux Kenneth K. Tanabe Mathias Heikenwälder Catherine Schuster Nathalie Pochet Mirjam B. Zeisel Bryan C. Fuchs Yujin Hoshida Thomas F. Baumert A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery Nature Communications |
| author_facet |
Emilie Crouchet Simonetta Bandiera Naoto Fujiwara Shen Li Hussein El Saghire Mirian Fernández-Vaquero Tobias Riedl Xiaochen Sun Hadassa Hirschfield Frank Jühling Shijia Zhu Natascha Roehlen Clara Ponsolles Laura Heydmann Antonio Saviano Tongqi Qian Anu Venkatesh Joachim Lupberger Eloi R. Verrier Mozhdeh Sojoodi Marine A. Oudot François H. T. Duong Ricard Masia Lan Wei Christine Thumann Sarah C. Durand Victor González-Motos Danijela Heide Jenny Hetzer Shigeki Nakagawa Atsushi Ono Won-Min Song Takaaki Higashi Roberto Sanchez Rosa S. Kim C. Billie Bian Karun Kiani Tom Croonenborghs Aravind Subramanian Raymond T. Chung Beate K. Straub Detlef Schuppan Maliki Ankavay Laurence Cocquerel Evelyne Schaeffer Nicolas Goossens Anna P. Koh Milind Mahajan Venugopalan D. Nair Ganesh Gunasekaran Myron E. Schwartz Nabeel Bardeesy Alex K. Shalek Orit Rozenblatt-Rosen Aviv Regev Emanuele Felli Patrick Pessaux Kenneth K. Tanabe Mathias Heikenwälder Catherine Schuster Nathalie Pochet Mirjam B. Zeisel Bryan C. Fuchs Yujin Hoshida Thomas F. Baumert |
| author_sort |
Emilie Crouchet |
| title |
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery |
| title_short |
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery |
| title_full |
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery |
| title_fullStr |
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery |
| title_full_unstemmed |
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery |
| title_sort |
human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-09-01 |
| description |
Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention. |
| url |
https://doi.org/10.1038/s41467-021-25468-9 |
| work_keys_str_mv |
AT emiliecrouchet ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT simonettabandiera ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT naotofujiwara ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT shenli ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT husseinelsaghire ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mirianfernandezvaquero ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT tobiasriedl ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT xiaochensun ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT hadassahirschfield ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT frankjuhling ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT shijiazhu ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT natascharoehlen ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT claraponsolles ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT lauraheydmann ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT antoniosaviano ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT tongqiqian ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT anuvenkatesh ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT joachimlupberger ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT eloirverrier ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mozhdehsojoodi ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT marineaoudot ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT francoishtduong ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT ricardmasia ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT lanwei ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT christinethumann ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT sarahcdurand ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT victorgonzalezmotos ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT danijelaheide ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT jennyhetzer ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT shigekinakagawa ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT atsushiono ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT wonminsong ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT takaakihigashi ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT robertosanchez ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT rosaskim ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT cbilliebian ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT karunkiani ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT tomcroonenborghs ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT aravindsubramanian ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT raymondtchung ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT beatekstraub ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT detlefschuppan ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT malikiankavay ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT laurencecocquerel ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT evelyneschaeffer ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT nicolasgoossens ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT annapkoh ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT milindmahajan ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT venugopalandnair ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT ganeshgunasekaran ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT myroneschwartz ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT nabeelbardeesy ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT alexkshalek ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT oritrozenblattrosen ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT avivregev ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT emanuelefelli ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT patrickpessaux ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT kennethktanabe ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mathiasheikenwalder ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT catherineschuster ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT nathaliepochet ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mirjambzeisel ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT bryancfuchs ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT yujinhoshida ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT thomasfbaumert ahumanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT emiliecrouchet humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT simonettabandiera humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT naotofujiwara humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT shenli humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT husseinelsaghire humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mirianfernandezvaquero humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT tobiasriedl humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT xiaochensun humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT hadassahirschfield humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT frankjuhling humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT shijiazhu humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT natascharoehlen humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT claraponsolles humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT lauraheydmann humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT antoniosaviano humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT tongqiqian humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT anuvenkatesh humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT joachimlupberger humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT eloirverrier humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mozhdehsojoodi humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT marineaoudot humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT francoishtduong humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT ricardmasia humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT lanwei humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT christinethumann humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT sarahcdurand humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT victorgonzalezmotos humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT danijelaheide humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT jennyhetzer humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT shigekinakagawa humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT atsushiono humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT wonminsong humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT takaakihigashi humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT robertosanchez humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT rosaskim humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT cbilliebian humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT karunkiani humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT tomcroonenborghs humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT aravindsubramanian humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT raymondtchung humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT beatekstraub humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT detlefschuppan humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT malikiankavay humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT laurencecocquerel humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT evelyneschaeffer humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT nicolasgoossens humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT annapkoh humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT milindmahajan humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT venugopalandnair humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT ganeshgunasekaran humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT myroneschwartz humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT nabeelbardeesy humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT alexkshalek humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT oritrozenblattrosen humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT avivregev humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT emanuelefelli humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT patrickpessaux humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT kennethktanabe humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mathiasheikenwalder humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT catherineschuster humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT nathaliepochet humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT mirjambzeisel humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT bryancfuchs humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT yujinhoshida humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery AT thomasfbaumert humanlivercellbasedsystemmodelingaclinicalprognosticliversignaturefortherapeuticdiscovery |
| _version_ |
1717375503231352832 |
| spelling |
doaj-454d7d31ae1e40b7812cd73b90a2e7e32021-09-19T11:48:40ZengNature Publishing GroupNature Communications2041-17232021-09-0112111910.1038/s41467-021-25468-9A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discoveryEmilie Crouchet0Simonetta Bandiera1Naoto Fujiwara2Shen Li3Hussein El Saghire4Mirian Fernández-Vaquero5Tobias Riedl6Xiaochen Sun7Hadassa Hirschfield8Frank Jühling9Shijia Zhu10Natascha Roehlen11Clara Ponsolles12Laura Heydmann13Antonio Saviano14Tongqi Qian15Anu Venkatesh16Joachim Lupberger17Eloi R. Verrier18Mozhdeh Sojoodi19Marine A. Oudot20François H. T. Duong21Ricard Masia22Lan Wei23Christine Thumann24Sarah C. Durand25Victor González-Motos26Danijela Heide27Jenny Hetzer28Shigeki Nakagawa29Atsushi Ono30Won-Min Song31Takaaki Higashi32Roberto Sanchez33Rosa S. Kim34C. Billie Bian35Karun Kiani36Tom Croonenborghs37Aravind Subramanian38Raymond T. Chung39Beate K. Straub40Detlef Schuppan41Maliki Ankavay42Laurence Cocquerel43Evelyne Schaeffer44Nicolas Goossens45Anna P. Koh46Milind Mahajan47Venugopalan D. Nair48Ganesh Gunasekaran49Myron E. Schwartz50Nabeel Bardeesy51Alex K. Shalek52Orit Rozenblatt-Rosen53Aviv Regev54Emanuele Felli55Patrick Pessaux56Kenneth K. Tanabe57Mathias Heikenwälder58Catherine Schuster59Nathalie Pochet60Mirjam B. Zeisel61Bryan C. Fuchs62Yujin Hoshida63Thomas F. Baumert64Institut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical SchoolInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDivision of Chronic Inflammation and Cancer, German Cancer Research CenterDivision of Chronic Inflammation and Cancer, German Cancer Research CenterLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical SchoolInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDepartment of Pathology, Massachusetts General HospitalDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical SchoolInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDivision of Chronic Inflammation and Cancer, German Cancer Research CenterDivision of Chronic Inflammation and Cancer, German Cancer Research CenterLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Sciences, Hiroshima UniversityDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiDepartment of Gastroenterological Surgery, Kumamoto UniversityDepartment of Pharmacological Sciences and Drug Discovery Institute, Icahn School of Medicine at Mount SinaiDivision of Liver Diseases, Icahn School of Medicine at Mount SinaiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiDepartment of Neurology, Harvard Medical SchoolDepartment of Neurology, Harvard Medical SchoolDepartment of Neurology, Harvard Medical SchoolLiver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical SchoolInstitute of Pathology, University Medicine, Johannes Gutenberg UniversityInstitute for Translational Immunology and Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical CenterUniversity of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 8204-CIIL- Center for Infection and Immunity of LilleUniversity of Lille, CNRS, Inserm, CHU Lille, Pasteur Institute of Lille, U1019-UMR 8204-CIIL- Center for Infection and Immunity of LilleCNRS UPR3572 Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire (IBMC)Division of Gastroenterology and Hepatology, Geneva University HospitalLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiDepartment of Neurology, Icahn School of Medicine at Mount SinaiRecanati/Miller Transplantation Institute, Icahn School of Medicine at Mount SinaiRecanati/Miller Transplantation Institute, Icahn School of Medicine at Mount SinaiMassachusetts General Hospital Cancer Center; Harvard Medical School, Cambridge St. CPZN 4216Broad Institute of Harvard and Massachusetts Institute of TechnologyBroad Institute of Harvard and Massachusetts Institute of TechnologyBroad Institute of Harvard and Massachusetts Institute of TechnologyInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical SchoolDivision of Chronic Inflammation and Cancer, German Cancer Research CenterInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDepartment of Neurology, Harvard Medical SchoolInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical SchoolLiver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical CenterInstitut National de la Santé et de la Recherche Médicale (Inserm), U1110, Institut de Recherche sur les Maladies Virales et HépatiquesDrug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.https://doi.org/10.1038/s41467-021-25468-9 |