Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

Abstract Background Novel anti-schistosomal multi-stage drugs are needed because only a single drug, praziquantel, is available for the treatment of schistosomiasis and is poorly effective on larval and juvenile stages of the parasite. Schistosomes have a complex life-cycle and multiple developmenta...

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Bibliographic Details
Main Authors: Alessandra Guidi, Fulvio Saccoccia, Nadia Gennari, Roberto Gimmelli, Emanuela Nizi, Cristiana Lalli, Giacomo Paonessa, Giuliana Papoff, Alberto Bresciani, Giovina Ruberti
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Parasites & Vectors
Subjects:
Schistosoma mansoni
HDAC inhibitors
Parasite reproductive systems
Online Access:http://link.springer.com/article/10.1186/s13071-018-3268-8

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http://link.springer.com/article/10.1186/s13071-018-3268-8

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