Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.

Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.

Chronic inflammation and subsequent fibrosis induced by mechanical stress play an important role in ligamentum flavum (LF) hypertrophy and degeneration in patients with lumbar spinal canal stenosis (LSCS). Angiopoietin-like protein 2 (Angptl2) is a chronic inflammatory mediator induced under various...

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Bibliographic Details
Main Authors: Takayuki Nakamura, Tatsuya Okada, Motoyoshi Endo, Tsuyoshi Kadomatsu, Takuya Taniwaki, Akira Sei, Haruki Odagiri, Tetsuro Masuda, Toru Fujimoto, Takafumi Nakamura, Yuichi Oike, Hiroshi Mizuta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3894965?pdf=render

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http://europepmc.org/articles/PMC3894965?pdf=render

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