ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues

ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues

Background: Monogenetic forms of amyotrophic lateral sclerosis (ALS) offer an opportunity for unraveling the molecular mechanisms underlying this devastating neurodegenerative disorder. In order to identify a link between ALS-related metabolic changes and neurodegeneration, we investigated whether A...

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Bibliographic Details
Main Authors: Hanna Bayer, Kerstin Lang, Eva Buck, Julia Higelin, Lara Barteczko, Noemi Pasquarelli, Jasmin Sprissler, Tanja Lucas, Karlheinz Holzmann, Maria Demestre, Katrin S. Lindenberg, Karin M. Danzer, Tobias Boeckers, Albert C. Ludolph, Luc Dupuis, Patrick Weydt, Anke Witting
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Lou Gehrig disease
PGC-1α
Lactate
FUS
SOD1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302509

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http://www.sciencedirect.com/science/article/pii/S0969996116302509

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