Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

Abstract Background The pathogenesis of contact dermatitis, a common inflammatory skin disease with limited treatment options, is held to be driven by inflammasome activation induced by allergens and irritants. We here aim to identify inflammasome‐targeting treatment strategies for irritant contact...

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Bibliographic Details
Main Authors: Hanna Bonnekoh, Carolina Vera, Angela Abad‐Perez, Silke Radetzki, Martin Neuenschwander, Edgar Specker, Niklas Amadeus Mahnke, Stefan Frischbutter, Eicke Latz, Marc Nazaré, Jens v. Kries, Marcus Maurer, Jörg Scheffel, Karoline Krause
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Clinical and Translational Allergy
Subjects:
autoinflammation
contact dermatitis
disulfiram
inflammasome
interleukin‐18
Online Access:https://doi.org/10.1002/clt2.12045

Internet

https://doi.org/10.1002/clt2.12045

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