sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression

sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression

Abstract Genetic regulation of gene expression, revealed by expression quantitative trait loci (eQTLs), exhibits complex patterns of tissue-specific effects. Characterization of these patterns may allow us to better understand mechanisms of gene regulation and disease etiology. We develop a constrai...

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Bibliographic Details
Main Authors: Yuan He, Surya B. Chhetri, Marios Arvanitis, Kaushik Srinivasan, François Aguet, Kristin G. Ardlie, Alvaro N. Barbeira, Rodrigo Bonazzola, Hae Kyung Im, GTEx Consortium, Christopher D. Brown, Alexis Battle
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Biology
Subjects:
Matrix factorization
Ubiquitous eQTLs
Tissue-specific eQTLs
Transcription factors
Online Access:http://link.springer.com/article/10.1186/s13059-020-02129-6

Internet

http://link.springer.com/article/10.1186/s13059-020-02129-6

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