Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

Persistent infection with HCMV is associated with the operation of diverse evasion phenotypes directed at antiviral immunity. Obstruction of intrinsic and innate immune responses is typically conferred by viral proteins either associated with the viral particle or expressed immediately after entry....

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Bibliographic Details
Main Authors: Sara Botto, Jinu Abraham, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Igor Landais, Daniel N. Streblow, Klaus J. Fruh, Victor R. DeFilippis
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
AIM2
DNA sensor
HCMV
IE2
IE86
STING
cGAS
cytomegalovirus
inflammasome
innate immunity
interferons
Online Access:https://doi.org/10.1128/mBio.02510-18

Internet

https://doi.org/10.1128/mBio.02510-18

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