The Gene Targeting Approach of Small Fragment Homologous Replacement (SFHR) Alters the Expression Patterns of DNA Repair and Cell Cycle Control Genes

The Gene Targeting Approach of Small Fragment Homologous Replacement (SFHR) Alters the Expression Patterns of DNA Repair and Cell Cycle Control Genes

Cellular responses and molecular mechanisms activated by exogenous DNA that invades cells are only partially understood. This limits the practical use of gene targeting strategies. Small fragment homologous replacement (SFHR) uses a small exogenous wild-type DNA fragment to restore the endogenous wi...

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Bibliographic Details
Main Authors: Silvia Pierandrei, Andrea Luchetti, Massimo Sanchez, Giuseppe Novelli, Federica Sangiuolo, Marco Lucarelli
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
arrayed gene expression
cell cycle control
DNA repair
gene targeting
SFHR
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300446

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http://www.sciencedirect.com/science/article/pii/S2162253117300446

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