A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants

A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants

Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder caused by mutations affecting UBE3A function. AS is characterized by intellectual disability, impaired motor coordination, epilepsy, and behavioral abnormalities including autism spectrum disorder features. The development o...

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Bibliographic Details
Main Authors: Monica Sonzogni, Ilse Wallaard, Sara Silva Santos, Jenina Kingma, Dorine du Mee, Geeske M. van Woerden, Ype Elgersma
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Molecular Autism
Subjects:
Angelman syndrome
UBE3A
Mouse model, behavior, drug screening
Online Access:http://link.springer.com/article/10.1186/s13229-018-0231-7

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http://link.springer.com/article/10.1186/s13229-018-0231-7

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