An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity.

An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity.

The individual risk for common diseases not only depends on genetic but also on epigenetic polymorphisms. To assess the role of epigenetic variations in the individual risk for obesity, we have determined the methylation status of two CpG islands at the POMC locus in obese and normal-weight children...

Full description

Bibliographic Details
Main Authors: Peter Kuehnen, Mona Mischke, Susanna Wiegand, Christine Sers, Bernhard Horsthemke, Susanne Lau, Thomas Keil, Young-Ae Lee, Annette Grueters, Heiko Krude
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3305357?pdf=render

Internet

http://europepmc.org/articles/PMC3305357?pdf=render

Similar Items