STAT5 is Expressed in CD34<sup>+</sup>/CD38<sup>−</sup> Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms

STAT5 is Expressed in CD34<sup>+</sup>/CD38<sup>−</sup> Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms

Janus kinase 2 (JAK2) and signal transducer and activator of transcription-5 (STAT5) play a key role in the pathogenesis of myeloproliferative neoplasms (MPN). In most patients, <i>JAK2</i> V617F or <i>CALR</i> mutations are found and lead to activation of various downstream...

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Bibliographic Details
Main Authors: Emir Hadzijusufovic, Alexandra Keller, Daniela Berger, Georg Greiner, Bettina Wingelhofer, Nadine Witzeneder, Daniel Ivanov, Emmanuel Pecnard, Harini Nivarthi, Florian K. M. Schur, Yüksel Filik, Christoph Kornauth, Heidi A. Neubauer, Leonhard Müllauer, Gary Tin, Jisung Park, Elvin D. de Araujo, Patrick T. Gunning, Gregor Hoermann, Fabrice Gouilleux, Robert Kralovics, Richard Moriggl, Peter Valent
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
MPN
STAT5
JAK2 V617F
neoplastic stem cells
Online Access:https://www.mdpi.com/2072-6694/12/4/1021

Internet

https://www.mdpi.com/2072-6694/12/4/1021

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