PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication

by Mulu Geletu, Zaid Taha, Patrick T. Gunning, Leda Raptis
Published 2019-02-01

Targeting STAT3 and STAT5 in Cancer

by Elvin D. de Araujo, György M. Keserű, Patrick T. Gunning, Richard Moriggl
Published 2020-07-01

Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Act...

by Katja Linher-Melville, Mina G Nashed, Robert G Ungard, Sina Haftchenary, David A Rosa, Patrick T Gunning, Gurmit Singh
Published 2016-01-01

Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis Inhibition

by Miriam Pons, Yanira Zeyn, Stella Zahn, Nisintha Mahendrarajah, Brent D. G. Page, Patrick T. Gunning, Richard Moriggl, Walburgis Brenner, Falk Butter, Oliver H. Krämer
Published 2021-07-01

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

by Elvin D. de Araujo, Anna Orlova, Heidi A. Neubauer, Dávid Bajusz, Hyuk-Soo Seo, Sirano Dhe-Paganon, György M. Keserű, Richard Moriggl, Patrick T. Gunning
Published 2019-11-01

Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.

by G Wei Xu, Julia I Toth, Sara R da Silva, Stacey-Lynn Paiva, Julie L Lukkarila, Rose Hurren, Neil Maclean, Mahadeo A Sukhai, Rabindra N Bhattacharjee, Carolyn A Goard, Bruno Medeiros, Patrick T Gunning, Sirano Dhe-Paganon, Matthew D Petroski, Aaron D Schimmer
Published 2014-01-01

STAT5 is Expressed in CD34⁺/CD38⁻ Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms

by Emir Hadzijusufovic, Alexandra Keller, Daniela Berger, Georg Greiner, Bettina Wingelhofer, Nadine Witzeneder, Daniel Ivanov, Emmanuel Pecnard, Harini Nivarthi, Florian K. M. Schur, Yüksel Filik, Christoph Kornauth, Heidi A. Neubauer, Leonhard Müllauer, Gary Tin, Jisung Park, Elvin D. de Araujo, Patrick T. Gunning, Gregor Hoermann, Fabrice Gouilleux, Robert Kralovics, Richard Moriggl, Peter Valent
Published 2020-04-01

Structural and functional consequences of the STAT5BN642H driver mutation

by Elvin D. de Araujo, Fettah Erdogan, Heidi A. Neubauer, Deniz Meneksedag-Erol, Pimyupa Manaswiyoungkul, Mohammad S. Eram, Hyuk-Soo Seo, Abdul K. Qadree, Johan Israelian, Anna Orlova, Tobias Suske, Ha T. T. Pham, Auke Boersma, Simone Tangermann, Lukas Kenner, Thomas Rülicke, Aiping Dong, Manimekalai Ravichandran, Peter J. Brown, Gerald F. Audette, Sarah Rauscher, Sirano Dhe-Paganon, Richard Moriggl, Patrick T. Gunning
Published 2019-06-01