Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis

Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis

Immunization with myelin components can elicit experimental autoimmune encephalomyelitis (EAE). EAE susceptibility varies between mouse strains, depending on the antigen employed. BL/6 mice are largely resistant to EAE induction with proteolipid protein (PLP), probably a reflection of antigen-specif...

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Bibliographic Details
Main Authors: Lei Wang, Julia Winnewisser, Christine Federle, Gregor Jessberger, Klaus-Armin Nave, Hauke B. Werner, Bruno Kyewski, Ludger Klein, Maria Hinterberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
experimental autoimmune encephalomyelitis
central tolerance
antigen presentation
thymic epithelium
epitope
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01511/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01511/full

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