Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.

Anthrax lethal toxin (LT) is a bipartite protease-containing toxin and a key virulence determinant of Bacillus anthracis. In mice, LT causes the rapid lysis of macrophages isolated from certain inbred strains, but the correlation between murine macrophage sensitivity and mouse strain susceptibility...

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Bibliographic Details
Main Authors: Zachary L Newman, Morton P Printz, Shihui Liu, Devorah Crown, Laura Breen, Sharmina Miller-Randolph, Pamela Flodman, Stephen H Leppla, Mahtab Moayeri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20502689/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20502689/?tool=EBI

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