VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures.

Vascular endothelial growth factor (VEGF) was first described as an angiogenic agent, but has recently also been shown to exert various neurotrophic and neuroprotective effects in the nervous system. These effects of VEGF are mainly mediated by its receptor, VEGFR-2, which is also referred to as the...

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Bibliographic Details
Main Authors: Litsa Nikitidou, Irene Kanter-Schlifke, Joke Dhondt, Peter Carmeliet, Diether Lambrechts, Mérab Kokaia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3395684?pdf=render