Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism.

Growth rate and yield are fundamental features of microbial growth. However, we lack a mechanistic and quantitative understanding of the rate-yield relationship. Studies pairing computational predictions with experiments have shown the importance of maintenance energy and proteome allocation in expl...

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Bibliographic Details
Main Authors: Chuankai Cheng, Edward J O'Brien, Douglas McCloskey, Jose Utrilla, Connor Olson, Ryan A LaCroix, Troy E Sandberg, Adam M Feist, Bernhard O Palsson, Zachary A King
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007066