Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells

Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells

Human cytomegalovirus (HCMV) primary infection and periodic reactivation of latent virus is generally well controlled by T-cell responses in healthy people. In older donors, overt HCMV disease is not generally seen despite the association of HCMV infection with increased risk of mortality. However,...

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Bibliographic Details
Main Authors: Sarah E. Jackson, George X. Sedikides, Georgina Okecha, Emma L. Poole, John H. Sinclair, Mark R. Wills
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
human cytomegalovirus
immunology of aging
viral latency
human cytomegalovirus-specific T-cells
IFNγ production
cIL-10+CD4+ T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00733/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00733/full

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