TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Abstract Background Low frequency coding variants in TREM2 are associated with Alzheimer disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD cases and controls. Similarly, TREM2 risk variant carriers also exhibit differential CSF TREM2 levels. TREM2 has thre...

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Bibliographic Details
Main Authors: Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari, Carlos Cruchaga
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Molecular Neurodegeneration
Subjects:
TREM2
RNAseq
Soluble TREM2
R47H
Alzheimer’s disease
Brain transcripts
Online Access:http://link.springer.com/article/10.1186/s13024-019-0319-3

Internet

http://link.springer.com/article/10.1186/s13024-019-0319-3

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