Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

Abstract Background Phospholipids in the central nervous system are enriched in n-3 and n-6 polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA) and arachidonic acid (ARA). These PUFA can undergo enzymatic reactions to produce lipid mediators, as well as reaction with oxygen fre...

Full description

Bibliographic Details
Main Authors: Bo Yang, Runting Li, C. Michael Greenlief, Kevin L. Fritsche, Zezong Gu, Jiankun Cui, James C. Lee, David Q. Beversdorf, Grace Y. Sun
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Neuroinflammation
Subjects:
Docosahexaenoic acid (DHA)
4-Hydroxyhexenal (4-HHE)
4-Hydroxynonenal (4-HNE)
Microglia
Lipopolysaccharide (LPS)
NO
Online Access:http://link.springer.com/article/10.1186/s12974-018-1232-3

Internet

http://link.springer.com/article/10.1186/s12974-018-1232-3

Similar Items