Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Abstract Background New strategies are needed to reduce the incidence of malaria, and promising approaches include the development of vaccines and monoclonal antibodies (mAbs) that target the circumsporozoite protein (CSP). To select the best candidates and speed development, it is essential to stan...

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Bibliographic Details
Main Authors: Rama Raghunandan, Bryan T. Mayer, Yevel Flores-Garcia, Monica W. Gerber, Raphael Gottardo, Hugo Jhun, Sonia M. Herrera, Daniel W. Perez-Ramos, Emily Locke, C. Richter King, Fidel Zavala
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Malaria Journal
Subjects:
Malaria
Transgenic parasite
Bioluminescence
Monoclonal antibodies
Functional activity
Circumsporozoite protein (CSP)
Online Access:http://link.springer.com/article/10.1186/s12936-020-03181-0

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http://link.springer.com/article/10.1186/s12936-020-03181-0

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