Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite

Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite

In recent years, onco-metabolites like D-2-hydroxyglutarate, which is produced in isocitrate dehydrogenase-mutated tumors, have gained increasing interest. Here, we report a metabolite in human specimens that is closely related to 2-hydroxyglutarate: the intramolecular ester of 2-hydroxyglutarate, 2...

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Bibliographic Details
Main Authors: Raffaela S. Berger, Christian J. Wachsmuth, Magdalena C. Waldhier, Kathrin Renner-Sattler, Simone Thomas, Anuhar Chaturvedi, Hans-Helmut Niller, Elisabeth Bumes, Peter Hau, Martin Proescholdt, Wolfram Gronwald, Michael Heuser, Marina Kreutz, Peter J. Oefner, Katja Dettmer
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
D-2-hydroxyglutarate
IDH1/2 mutation
lactonization
acute myeloid leukemia
Online Access:https://www.mdpi.com/2072-6694/13/8/1756

Internet

https://www.mdpi.com/2072-6694/13/8/1756

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