Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model

Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model

The universal modular chimeric antigen receptor (UniCAR) platform redirects CAR-T cells using a separated, soluble targeting module with a short half-life. This segregation allows precise controllability and flexibility. Herein we show that the UniCAR platform can be used to efficiently target solid...

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Bibliographic Details
Main Authors: Elham Pishali Bejestani, Marc Cartellieri, Ralf Bergmann, Armin Ehninger, Simon Loff, Michael Kramer, Johannes Spehr, Antje Dietrich, Anja Feldmann, Susann Albert, Martin Wermke, Michael Baumann, Mechthild Krause, Martin Bornhäuser, Gerhard Ehninger, Michael Bachmann, Malte von Bonin
Format: Article
Language:English
Published: Taylor & Francis Group 2017-10-01
Series:OncoImmunology
Subjects:
chimeric antigen receptors
immune checkpoints
immunoevasion
prostate stem cell antigen
solid tumors
targeting module
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1342909

Internet

http://dx.doi.org/10.1080/2162402X.2017.1342909

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