Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors (gender, diet, smoking, alcohol, exercise) that,...

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Bibliographic Details
Main Authors: Fotios Drenos, Thomas B L Kirkwood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2848859?pdf=render