Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

Objective: Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains unclear. Methods: To identify pathways related to i...

Full description

Bibliographic Details
Main Authors: Carles Lerin, Allison B. Goldfine, Tanner Boes, Manway Liu, Simon Kasif, Jonathan M. Dreyfuss, Ana Luisa De Sousa-Coelho, Grace Daher, Irini Manoli, Justin R. Sysol, Elvira Isganaitis, Niels Jessen, Laurie J. Goodyear, Kirk Beebe, Walt Gall, Charles P. Venditti, Mary-Elizabeth Patti
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877816301156

Internet

http://www.sciencedirect.com/science/article/pii/S2212877816301156

Similar Items