Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.

Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.

<h4>Background</h4>The Ikkα kinase, a subunit of the NF-κB-activating IKK complex, has emerged as an important regulator of inflammatory gene expression. However, the role of Ikkα-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplored. In this study, we investiga...

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Bibliographic Details
Main Authors: Pathricia V Tilstam, Marion J Gijbels, Mohamed Habbeddine, Céline Cudejko, Yaw Asare, Wendy Theelen, Baixue Zhou, Yvonne Döring, Maik Drechsler, Lukas Pawig, Sakine Simsekyilmaz, Rory R Koenen, Menno P J de Winther, Toby Lawrence, Jürgen Bernhagen, Alma Zernecke, Christian Weber, Heidi Noels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498325/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498325/pdf/?tool=EBI

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