Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.

Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.

The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have evolved. These include changes in its active s...

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Bibliographic Details
Main Authors: Suresh Marada, Gemma Navarro, Ashley Truong, Daniel P Stewart, Angela M Arensdorf, Sigrid Nachtergaele, Edgar Angelats, Joseph T Opferman, Rajat Rohatgi, Peter J McCormick, Stacey K Ogden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4546403?pdf=render

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http://europepmc.org/articles/PMC4546403?pdf=render

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